Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains.
lipid droplets (LDs) is the endoplasmic reticulum (ER) -derived lipid storage organelles is uniquely packed by phospholipid monolayers. LD membrane proteins are embedded into the topology monolayer monotopic hairpin and therefore tend to have different requirements for their biogenesis of people Insert as bitopic and polytopic protein to phospholipid bilayers. UBXD8 hairpin belonging to subfamily […]
Localization of a Trypanosome Peroxin to the Endoplasmic Reticulum.
Trypanosoma brucei is the causative agent of diseases that affect 30,000-50,000 people annually. Trypanosoma brucei harbor unique organelles called glycosomes essential for the survival of the parasite, which requires growth under fluctuating environmental conditions. The mechanisms that regulate biogenesis of these organelles are poorly understood. Glycosomes evolutionary related to the peroxisomes, which can proliferate de […]
Peroxisomes Extend Peroxules in a Fast Response to Stress via a Reactive Oxygen Species-Mediated Induction of the Peroxin PEX11a.
Peroxisome is an organelle that is very dynamic and is metabolically active which play important roles in cell function, including reactive oxygen species (ROS) metabolism. peroxisomal dynamics, such as proliferation, movement, and dynamic extension called peroxules production, has been associated with ROS in plant cells. However, the function and regulation of peroxules largely unknown. Using […]
A New Yeast Peroxin, Pex36, a Functional Homolog of Mammalian PEX16, Functions in the ER-to-Peroxisome Traffic of Peroxisomal Membrane Proteins.
peroxisomal membrane proteins (PMPs) traffic to peroxisomes by two mechanisms: direct insertion from the cytosol to the membrane peroxisomal and indirect trade to peroxisomes via the endoplasmic reticulum (ER). In mammalian and yeast, traffic through the ER with a few PMPs Pex3- and Pex19 dependent manner. In Komagataella phaffii (formerly called Pichia pastoris) special, indirect […]